Cancer microenvironment controlled by cancer-derived exosomes
Cancer-derived exosomes trigger epithelial to mesenchymal transition (EMT). Yet, an enabling tool in vitro has not been available to investigate how cancer-derived exosomes induce endothelial to mesenchymal transition (EndMT) and lead to the cancer-associated fibroblast (CAF) differentiation. We uses a microfluidic model for monitoring a synergetic effect on the EndMT by controlling both interstitial flow and exogenous concentration of the cancer-derived exosomes.
Development of therapeutics derived from nanovesicles
Exosomes are nanometer-sized extracellular vesicles secreted from diverse cells involved in intercellular communications. We would develop nanovesicles as new therapeutics for cancer and alzheimer's disease. We have especially focused on South Korea's traditional edible plant sap or extract to discover therapeutic candidates.
Development of disease model based on artificial blood vessel
The blood vessels are the part of the circulatory system that transports blood throughout the human body and essential for various disease models. We have developed perfusable artificial blood vessel in a microfluidic device and applied for reconstituting tissue and organ in vitro. Artificial blood vessel is essential for developing all kind of disease models in vitro.